Is this Sean Peyton's last game as the Saints head coach?
Does Mario Williams play a snap?
How will Rex Ryan be coaching his former team for the second time?
Can Doug Martin take the rushing title from AP?
Can Ezekiel Ansah become the sacks leader?
Is it Jim Caldwell's last game?
Is this Adam Gase's last game as the Bears offensive coordinator before he gets a head coaching job?
Can Carlos Dunlap get the sacks title?
Will Reggie Nelson take the interceptions title?
Will the Browns get the first overall pick?
Is it Mike Pettine's last game as the Browns head coach?
Will the Browns get the 1st overall pick?
Will the Cowboys be a top 5 pick?
Will Adrian Peterson become the rushing champion for the first time since 2012?
Can DeAndre Hopkins lead the league in receiving yards?
Can J.J. Watt take the lead the lead in sacks?
Is it Gus Bradley's last game as the Jaguars head coach?
Will the Titans get the first overall pick?
Can D'Qwell Jackson be the league leader in tackles?
What who will start at QB for the Colts?
Is this the last game as the Oakland Raiders before they move to L.A.?
How will Odell Beckham Jr. play after his 1 game suspension?
Can Carson Palmer take the passing title from Tom Brady?
Is this the last game for Mike McCoy as the Chargers head coach?
Can Philip Rivers take the passing title from Brady?